Melissa E. Murray, Ph.D., and her colleagues in Mayo Clinic's Translational Neuropathology Lab ( https://www.mayo.edu/research/labs/translational-neuropathology) use a multidisciplinary approach that integrates neuropathology, neuroimaging and genetics to investigate neurocognitive disorders (Alzheimer's disease), parkinsonian disorders (dementia with Lewy bodies) and motor neuron disorders (Lou Gehrig's disease). Dr. Murray is specifically interested in the effect of brain aging overlaid with a neurodegenerative disorder. The lab has revealed striking differences regarding vulnerability or resilience in affected individuals, especially in the setting of Alzheimer's disease (AD).