My research aims to uncover the biological principles that govern adaptation, plasticity, and resilience across aging and disease. Using the aging brain as a model system, I investigate how immune signaling, lipid metabolism, lysosomal biology, and cellular state transitions coordinate adaptive responses that preserve function or drive dysfunction. By integrating genetics, multi-omics, spatial biology, and longitudinal analyses, I aim to define the molecular and cellular mechanisms that shape biological aging and identify opportunities for therapeutic intervention. A central goal of my research program is to understand why some biological systems remain resilient while others transition toward dysfunction, and how these adaptive trajectories can be measured, predicted, and ultimately reprogrammed. Looking forward, I aspire to uncover universal principles of adaptive biology, including those found in exceptional human aging and natural models of extreme adaptation, and translate these discoveries into innovative strategies that promote healthy aging, preserve brain health, and improve human resilience. 1. Adaptation - What determines biological adaptation and resilience? 2. Plasticity - How do biological systems change across aging and disease? 3. Transformation - Can aging be measured, predicted, and reprogrammed? 4. Translation - Can nature's adaptive strategies improve human health? Our goal: We aim to understand how cells sense and adapt to changing biological environments, and why some adaptive responses promote resilience while others lead to dysfunction and disease.