Research in our laboratory focuses on mechanisms underlying the regulation of gene expression and how these mechanisms are disrupted in neurodegenerative diseases. We use high-throughput functional genomics and genetic association studies to identify regions of the genome with functional effects on tissues and cells of the brain. We apply methods from statistical and population genetics to large-scale genotyping and sequencing studies to discover novel susceptibility alleles for age-related cognitive decline and Alzheimer’s disease.
We collaborate extensively with colleagues to develop and apply methods for constructing causal regulatory networks to understand mechanisms driving complex diseases. Our work is primarily computational, with an emphasis on integrative data analysis and the development of statistical and computational approaches, but we often work closely with experimental biologists