My laboratory is focused on understanding the complex communication taking place between the systemic environment and the brain in the context of neurodegenerative diseases. We areparticularly interested in characterizing the activity of TIMP2 and related proteins and theiraction in mediating long-range effects on neural circuits in the context of disease. We leverageboth systems approaches as well as conventional molecular, cellular, and behavioral methodologies to understand how the brain’s learning and memory circuits are shaped by these systemic influences