Dr. Wolozin’s interests focus on the pathophysiology of Alzheimer’s and Parkinson’s disease. His work on Alzheimer’s disease examines the role of cholesterol in the pathophysiology of Alzheimer’s disease, and stems from his discovery in 2000 that subjects taking the cholesterol lowering medicines, termed statins, have a lower incidence of Alzheimer’s disease. His work on Parkinson’s disease examines the interaction between genes implicated in the disease, such as parkin and a -synuclein, and environmental factors implicated in the disease.
He uses a wide range of approaches to study neurodegenerative disease ranging from molecular approaches to epidemiology. These approaches include molecular biology, cellular biology, transgenic mice, transgenic C. elegans, study of human brain samples and epidemiological database analyses.